Postbiotics

Heat-Treated Lactic Acid Bacteria

Strain

Raw Material (Strain)

1. De-glu GLU70(GLU70)

2. De-glu MB0601(MB0601)

3. Dipro-rhamnosus(DS0508)

4. Heat-treated strain MB201(ML-004)
5. Heat-treated strain MB202(ML-036)
6. Heat-treated strain MB203(ML-019)
7. Heat-treated strain MB204(ML-035)

Function

1. Gluten-degrading activity; Preventing, improving, or treating gliadin-induced inflammatory bowel disease (Patented)

2. Gluten-degrading activity (Patented)

3. Obesity treatment and prevention

Contains 17 kinds of amino acids and various organic acids and short-chain fatty acids

De-glu MB1

Heat-treated and dried MB0601 strain with gluten-degrading activity

Equally effective as probiotics

Prebiotic actions

Enhanced stability

Versatility of application

De-glu MB1 dry powder

De-glu MB2

A composition for preventing, improving, or treating gliadin-induced inflammatory bowel disease comprising of heat-killed GLU70 as an active ingredient having gluten degradation

Normal intestinal epithelial cell

Intestinal epithelial cells damaged by gliadin

Degeneration of damaged intestinal epithelial cells inhibited by De-glu MB2

Confirmed inhibition of gluten(gliadin)-induced degeneration of intestinal epithelial cells by De-glu MB2

Decreased secretion of TNF-α (inflammatory cytokine)

Increased secretion of IL-10
(anti-inflammatory cytokine)

Decreased expression levels of inflammatory
proteins in De-glu GLU70-ingested groups

Reduced secretion of inflammatory cytokines, increased secretion of anti-inflammatory cytokines, and decreased expression of inflammatory proteins by De-glu MB2 strain

Dipro-rhamnosus heat-treated strain

Animal Model Experiment (In vivo test)

To test the weight gain inhibition effect by the novel strain, high fat diet-induced obese mice were administered the strain or the culture medium for 12 weeks